Sucralose is a popular artificial sweetener that is commonly used in a variety of food and beverage products as a sugar substitute. It is widely considered safe for consumption by regulatory bodies such as the FDA and EFSA. When consumed, most of the sucralose passes through the body without being metabolized, meaning it is not broken down by the body for energy like other nutrients. Instead, sucralose is excreted largely unchanged in the feces.

However, a small portion of ingested sucralose is metabolized in the body. This process involves the cleavage of the carbon-chlorine bond in the molecule, which results in the formation of metabolites such as 1,6-dichlorofructose, 4-chloro-4-deoxygalactose, and 1,6-dichlorogalactitol. These metabolites are eventually excreted in the urine.

Research has shown that the metabolism of sucralose in the human body is minimal, with less than 15% of ingested sucralose being metabolized. The majority of the sweetener is excreted unchanged, making it a non-caloric and non-nutritive substance.

The metabolism of sucralose has been extensively studied in both animal and human studies. These studies have shown that sucralose is not absorbed into the bloodstream to any significant extent and is excreted relatively quickly from the body. The metabolites of sucralose are also considered to be safe and do not raise any concerns regarding toxic effects.

Overall, the metabolism of sucralose in the body is minimal, with the sweetener being excreted largely unchanged in the feces. The small portion of sucralose that is metabolized produces safe and non-toxic metabolites that are eventually excreted in the urine. This metabolism pathway contributes to the safety profile of sucralose and is one of the reasons why it is considered a safe alternative to sugar for individuals looking to reduce their calorie intake.